Throughout history, humanity has become sick and has devoted considerable attention to know the reason of diseases, encompassing their aetiology and cures. The field of molecular science has undergone remarkable growth and advancement over time.

Notably, the turnaround of snake venom in the development of medicines for treatment of various ailments such as cancer, cardiovascular disorders, Parkinson’s disease, and Alzheimer’s disease has been well-known. Snake venom has also served as a boon in experimental process in formulation of antivenom.

Presently, unique opportunity has come up in the study of the Asp Caterpillar, offering a recent route for exploration and future discovery.

Asp Caterpillar? What is it?

• Common Name: Asp Caterpillar/Puss Caterpillar/Flannel Moth Larvae
• Scientific Name: Megalopyge opercularis
• Habitat: Trees & Shrubs in North America
• Size: Just 1 Inch

However, it’s important not to underestimate this insect based on its size alone. The sting from the Asp Caterpillar can result in intense pain, burning sensations, swelling, and potentially severe allergic reactions.

What is so special about the sting of an Asp Caterpillar?

According to a publication in Proceedings of National Academy of Sciences, The venom of the asp caterpillar contains a unique protein that is abundant in aerolysin-like proteins and peptides, demonstrating a fascinating ability to change shape and punch holes. When it comes in contact with the outer surface of cell wall, this protein triggers a shape shifting into a doughnut shape and then punches a pore in the cell membrane facilitating the passage of ions and small molecules.

Reputed Research fellow Dr. Andrew Walker at Institute of Molecular Biosciences revealed in an interview with Australian Broadcasting Corporation that “We might be able to engineer these kinds of toxins to target cancer cells or to target pathogens while leaving human cells alone.”

It is reasonable to anticipate that within the next 10 to 15 years, researchers may pursue this mechanism to develop a cancer-treating protein capable of selectively killing cancer cells while sparing healthy human cells. Such an advancement holds the potential to alleviate the side effects commonly associated with existing cancer treatments.